In January 2008, MATTHEW WALKER COMPREHENSIVE HEALTH CENTER opened a new clinic in Clarksville, TN in response to a federal call for community health centers to fill the gap in medical treatment in under-served communities. The clinic provides primary and dental care for adults and children. Some on-site healthcare services include internal medicine, pediatrics, geriatric medicine, immunizations, physicals, nutrition and preventative and restorative dental care. In keeping with the Matthew Walker mission, vision and values "we ensure that the necessary healthcare services we provide are accessible and affordable to the communities we serve".

The center serves anyone with TennCare, Medicare and most private health insurance. Patients without insurance can apply and have the cost of visits, labs and medications reduced based on verified income. Nominal co-payments are expected at the time of the appointment.